Phenotypes and Clinical Genotypes of Bruxism Patients: A Systematic Review

Background. Bruxism is a phenomenon where psychological and exogenous biological factors act in greater percentage. Several genetic polymorphisms have been described GABAA receptors, some associated with motor limitations, such as the rs1805057 polymorphism of GABRB1 gene (GABAA), which found haplotype lower limitation movement acute pain processes. The aim to identify clinical phenotypes bruxism patients. Eligibility criteria were follows: observational studies, case control odds ratios, bruxism, patients, keyword search that included [[bruxism]], OR [[temporomandibular joint disorders]] [[sleep bruxism]], [[awake [[polymorphism]] or [[GABAA]], [[serotonin]] , using Boolean operators AND, NOT. Were 210 identified records databases; 50 from other sources; 117 deleted after determining they duplicates; 42 studies qualitative synthesis ; finally, who met inclusion requirements 5 synthesis. comparison global DNA methylation profiles patients shows possible influence on their etiology, indicating HTR2A rs2770304 alleles are at increased risk. allele leads an risk bruxism.